Jpn. J. Pharmacol. 75 (3), 299-301 (1997)

Effects of Streptozotocin-Induced Diabetes on Place Conditioning Action of Cocaine in Mice

Junzo Kamei and Masahiro Ohsawa

Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Science, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142, Japan

Abstract: The effect of diabetes on the cocaine-induced place conditioning in mice was examined. In non-diabetic mice, cocaine, at dose ranges from 1 to 30 mg/kg, s.c. caused a dose-related preference for the drug-associated place, and significant place conditioning was observed at 10 and 30 mg/kg. In diabetic mice, cocaine at a dose of 10 mg/kg, s.c. did not produce a significant place preference, but a significant place conditioning was observed at 30 mg/kg. These results suggest that the reinforcing property of cocaine in diabetic mice was less than that in non-diabetic mice.

Keywords: Diabetes, Cocaine, Place preference

Copyrightę The Japanese Pharmacological Society 1997

[Back to TOC]