Jpn. J. Pharmacol. 75 (2), 199-201 (1997)

Effects of Concanavalin A on Cytokine mRNA Expression in Mouse Liver

Toshihiro Okamoto and Tadashi Kobayashi

Research Laboratories, Nippon Chemiphar Co., Ltd., 1-22 Hikokawato, Misato, Saitama 341, Japan

Abstract: The effects of concanavalin A (Con A) on liver cytokine gene expression was studied in mice. The CD4 mRNA expression in normal liver suggests the presence of CD4+ T cells. The administration of Con A induced interleukin (IL)-1beta, IL-2 and IL-2 receptor mRNAs, which implies lymphocyte activation in the liver. Interferon-gamma and tumor necrosis factor-alpha mRNA expressions were increased gradually. The present results showed that Con A induced liver cytokine genes. This cytokine gene induction might have been the result of lymphocyte activation in the liver.

Keywords: Concanavalin A, Liver, Cytokine mRNA

Copyrightę The Japanese Pharmacological Society 1997

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