Takumi Kumamoto, Akihiko Matsuda, Mikiko Kataoka and Yukifumi Kokuba
Development Laboratories, Research and Development Division, Nippon Hoechst Marion Roussel Ltd, Shiga 520-23, Japan
Abstract: To clarify the mode of action of aminosalicylates, which are generally used as therapeutic agents for ulcerative colitis, we investigated the effect of some of the aminosalicylates on lipid peroxidation in the large intestinal mucosa after mesenteric ischemia/reperfusion in the rat. Lipid peroxidation was assessed by measuring the level of thiobarbituric-acid-reactive substances. It was found that aminosalicylates dose-dependently inhibited the elevation of the level of thiobarbituric-acid-reactive substances in the large intestinal mucosa after ischemia/reperfusion. This effect may partly contribute to the therapeutic actions of aminosalicylates in ulcerative colitis.
Keywords: Lipid peroxidation, Ischemia/reperfusion, Large intestinal mucosa