Jpn. J. Pharmacol. 74 (2), 221-224 (1997)

The Novel Anti-Rheumatic Drug TA-383 Has a Macrophage Migration Enhancing Activity

Makoto Ueno, Takahisa Sugita, Takanori Murakami and Isao Takata

Lead Generation Research Laboratory, Tanabe Seiyaku Co., Ltd., 3-16-89 Kashima, Yodogawa-ku, Osaka 532, Japan

Abstract: We have investigated the effect of a novel anti-rheumatic drug, cis-2-(4-chlorophenyl)-4,5-diphenyl-2-imidazoline hydrochloride (TA-383), on macrophages. TA-383 (>- 10-9 M) significantly stimulated rabbit alveolar macrophage (AM) migration, and its migration-stimulatory activity was more potent than those of L-fucose (5 x 10-3 M), lobenzarit disodium, bucillamine (SA-96) and salazosulfapyridine. In addition, TA-383 enhanced the production and/or release of macrophage migration enhancement factor by rabbit spleen cells. In vivo, TA-383 (0.4 mg/kg, p.o.) has suppressive effects on picryl chloride-induced delayed type hypersensitivity and type II collagen-induced arthritis in mice. These results suggest that the anti-rheumatic activity of TA-383 may be exerted through the dispersion of macrophages from inflammatory sites.

Keywords: TA-383, Macrophage migration enhancement activity, Collagen-induced arthritis

Copyrightę The Japanese Pharmacological Society 1997

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