Katsukiyo Sakurai (1, 2), Mariko Andoh (1), Motoyuki Yamada (1), Yoh Kodera (1), Hiroyuki Nishimura (1), Misao Hiroto (1), Ayako Matsushima (1), Masaaki Aoyama (3), Hisao Yamamoto (2) and Yuji Inada (1,*)
(1) Toin Human Science and Technology Center, Department of Materials
Science and Technology, Toin University of Yokohama, Aoba-ku, Yokohama 225,
(2) The Tokyo Research Institute, Seikagaku Corporation, Higashiyamato, Tokyo 207, Japan
(3) Institute for Life Support Technology, Yamagata Technopolis Foundation, Numagi, Yamagata 990, Japan
(*) To whom correspondence should be addressed.
Abstract: Manganese-hyaluronate conjugate (Mn-HA) was synthesized from a diethylenetriaminepentaacetic acid derivative of hyaluronic acid and manganese ion. The conjugate markedly scavenged superoxide anion in vitro and exhibited much higher anti-inflammatory activity than superoxide dismutase in suppressing paw edema in mice when intravenously injected 30 min before the initiation of ischemia.
Keywords: Manganese-hyaluronate conjugate, Ischemic edema, Reactive oxygen species