Mayumi Suzuki, Nobuyuki Kishibayashi, Toshihide Yokoyama and Akira Karasawa
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411, Japan
Abstract: We examined the effect of KW-5092, a gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release facilitatory activities, on the peristalsis of isolated guinea pig ileum. KW-5092 (10-9 - 3 x 10-6 M) increased the frequency of the peristaltic wave without changing its amplitude. Neostigmine increased the frequency at 10-7 M, but domperidone (10-8 - 3 x 10-6 M) had no effect on the peristalsis. The present results suggest that KW-5092 enhances the peristalsis via the inhibition of acetylcholinesterase, resulting in the intestinal propulsion.
Keywords: Peristalsis, Ileum, Acetylcholine