Jpn. J. Pharmacol. 74 (1), 91-94 (1997)


Effect of KW-5092, Novel Gastroprokinetic Agent, on the Peristalsis in the Isolated Guinea Pig Ileum

Mayumi Suzuki, Nobuyuki Kishibayashi, Toshihide Yokoyama and Akira Karasawa

Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411, Japan

Abstract: We examined the effect of KW-5092, a gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release facilitatory activities, on the peristalsis of isolated guinea pig ileum. KW-5092 (10-9 - 3 x 10-6 M) increased the frequency of the peristaltic wave without changing its amplitude. Neostigmine increased the frequency at 10-7 M, but domperidone (10-8 - 3 x 10-6 M) had no effect on the peristalsis. The present results suggest that KW-5092 enhances the peristalsis via the inhibition of acetylcholinesterase, resulting in the intestinal propulsion.

Keywords: Peristalsis, Ileum, Acetylcholine


Copyrightę The Japanese Pharmacological Society 1997

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