Jpn. J. Pharmacol. 73 (4), 353-356 (1997)

Effect of Japanese Angelica Root Extract on Pentobarbital-Induced Sleep in Group-Housed and Socially Isolated Mice: Evidence for the Central Action

Kinzo Matsumoto (1), Shin-ichi Kohno (1), Yasuhiro Tezuka (2), Shigetoshi Kadota (2) and Hiroshi Watanabe (1)

(1) Department of Pharmacology, (2) Department of Natural Products Chemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan

Abstract: We investigated the effect of the aqueous extract of Japanese angelica root (JAR) on pentobarbital (PB) sleep in group-housed and socially isolated mice. The JAR extract (1.25 - 2.5 g/kg, p.o.) dose-dependently reversed the decrease in PB sleep caused by isolation stress without affecting PB sleep in group-housed mice. The JAR extract (2.5 g/kg, p.o.) also antagonized the decrease in PB sleep caused by the alpha2-adrenoceptor antagonists yohimbine and idazoxan (1 mg/kg, i.p.) and the alpha1-adrenoceptor agonist methoxamine (200 nmol, i.c.v.) in group-housed mice. These results suggest that the JAR extract reverses changes in the arousal level caused by isolation stress and the activation of central noradrenergic systems.

Keywords: Angelicae radix, Social isolation stress, Pentobarbital sleep

Copyrightę The Japanese Pharmacological Society 1997

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