Jpn. J. Pharmacol. 73 (3), 247-250 (1997)

Persistence of Cyclopiazonic Acid-Induced Endothelium-Dependent Vasodilatation in Spontaneously Hypertensive and Streptozotocin-Induced Diabetic Rats

Katsuo Kamata, Tsuyoshi Hayashi and Fujio Umeda

Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142, Japan

Abstract: We recently reported that cyclopiazonic acid (CPA) releases a novel endothelium-derived relaxing factor that is not prostacyclin, nitric oxide or endothelium-derived hyperpolarizing factor in rat mesenteric arterial bed. The acetylcholine-induced vasodilatation of the isolated mesenteric bed in spontaneously hypertensive rats (SHR) was not different from that in Wistar Kyoto rats (WKY), but it was significantly smaller in streptozotocin (STZ)-induced diabetic rats than in age-matched controls. The CPA-induced vasodilatation was not affected in SHR or in STZ-induced diabetic rats. These results suggest that the CPA-induced endothelium-dependent vasodilatation is resistant to the effects of diabetes.

Keywords: Cyclopiazonic acid, Diabetes, Endothelium-derived relaxing factor

Copyrightę The Japanese Pharmacological Society 1997

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