Yuka Okui (1), Masufumi Morita (1), Akira Iizuka (1), Yasuhiro Komatsu (1), Minoru Okada (1), Masao Maruno (1) and Akira Niijima (2)
(1) Central Research Laboratory, Tsumura & Co., 3586 Ami-machi, Yoshiwara, Inasiki-gun, Ibaraki 300-11, Japan (2) Department of Physiology, Niigata University School of Medicine, Niigata 951, Japan
Abstract: Hoelen is used to treat gastric disease in Eastern traditional medicine. The efferent activity on the gastric vagus nerve was studied in the rat, and the activity was found to increase after administration of Hoelen into the duodenum. In addition, we examined the effect of Hoelen fractions. Both the fraction containing polysaccharide and the triterpenoid-rich fraction increased activity significantly. Hoelen would thus appear useful for treating gastric disease by activating efferent activity of the gastric vagus nerve through the action of triterpenoid and polysaccharide.
Vagus nerve, Gastric branch, Hoelen
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