Hirokazu Kawasaki, Haruhiko Manabe and Kenji Ohmori
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411, Japan
Abstract: We investigated the effect of KW-4679 ((Z)-11-[(3-dimethylamino)propylidene]- 6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride), an orally active anti-allergic drug, on antigen-induced airway hyperresponsiveness using two different indicators, pulmonary resistance (RL) and dynamic lung compliance (Cdyn), in actively sensitized guinea pigs. Oral administration of KW-4679 (0.1 and 1 mg/kg) 1 hr before aerosolized antigen exposure significantly inhibited the development of airway hyperresponsiveness to inhaled acetylcholine in RL and Cdyn in a dose-dependent manner. Terfenadine (10 mg/kg) also inhibited the development of airway hyperresponsiveness. These results indicate that KW-4679 could be useful in the treatment of bronchial asthma.
KW-4679, Airway hyperresponsiveness
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