Jpn. J. Pharmacol. 70 (1), 85-88 (1996)

Effects of the Mycelial Extract of Cultured Cordyceps Sinensis on In Vivo Hepatic Energy Metabolism in the Mouse

Noboru Manabe (1), Miki Sugimoto (1), Yasuyoshi Azuma (1), Naoki Taketomo (2), Akio Yamashita (3), Hiroshi Tsuboi (2), Akinobu Tsunoo (2), Noriko Kinjo (4), Huang Nian-Lai (5) and Hajime Miyamoto (1)

(1) Department of Animal Science, Faculty of Agriculture, Kyoto University, Kyoto 606-01, Japan (2) Meiji Institute of Health Science, Meiji Milk Products Co., Ltd., Odawara 250, Japan (3) Meiji Cell Technology Center, Meiji Milk Products Co., Ltd., Odawara 250, Japan (4) Department of General Education, Tokyo Medical and Dental University, Ichikawa 272, Japan (5) Sanming Mycological Institute, Fujian, People's Republic of China

Abstract: Mice were given the extract of cultured Cordyceps sinensis (Cs) (200 mg/kg daily, p.o.) for 3 weeks. In vivo phosphorus-31 nuclear magnetic resonance (NMR) spectra of the liver were acquired at weekly intervals using a surface coil. From 1 to 3 weeks, a consistent increase in the ATP/inorganic phosphate ratio, which represents the high energy state, was observed in the Cs extract-treated mice. The intracellular pH of the Cs extract-treated mice was not significantly different from that of the control mice. No steatosis, necrosis, inflammation or fibrosis were observed in the liver specimens from Cs extract-treated mice.

Keywords: Liver energy state, Phosphorus-31 nuclear magnetic resonance (NMR) (in vivo)

Copyright© The Japanese Pharmacological Society 1996

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