Jpn. J. Pharmacol. 69, 443-445 (1995)

Effect of Levofloxacin-Albumin Dacron Graft on Graft Infection

Katsuhiro Fujimoto (1), Keiko Yamamura (2,*), Tetsuo Hayashi (2), Takashi Osada (2) and Tsunehisa Sakurai (1)

(1) First Department of Surgery, (2) Department of Hospital Pharmacy, Nagoya University School of Medicine, Tsuruma-cho, Showa-ku, Nagoya 466, Japan

Abstract: The susceptibility of Dacron grafts to infection is compared with Dacron grafts applied with levofloxacin-bonded albumin (LVFX-ALB) following the inoculation of 10-7 cells Staphylococcus aureus in rats. Staphylococcus epidermidis was inoculated in the same manner. While the control grafts were infected at the time of removal, the LVFX-ALB Dacron grafts resisted infection, thus demonstrating their effectiveness.

Keywords: Levofloxacin, Albumin, Graft infection

Copyright© The Japanese Pharmacological Society 1995

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