Jpn. J. Pharmacol. 69, 439-442 (1995)

Enhancement of Hepatic Glutathione Regeneration Capacity by a Lignan-Enriched Extract of Fructus Schisandrae in Rats

Kam-Ming Ko (*), Duncan H.F. Mak, Pui-Chun Li, Michel K.T. Poon and Siu-Po Ip

Department of Biochemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong

Abstract: Exposure of liver homogenates to an in vitro tert-butyl hydroperoxide challenge can be used as a means for measuring the reduced glutathione regeneration capacity (GRC) of hepatic tissues. Pretreatment of rats with a lignan-enriched extract of Fructus Schisandrae (FS) caused a moderate enhancement of hepatic GRC in control rats but the GRC enhancing effect of FS pretreatment on hepatic tissues was greatly exaggerated after CCl4 challenge. This in vitro bioassay can be used for investigating the hepatic GRC promoting action of orally active agents.

Keywords: Schisandra chinensis, Glutathione regeneration capacity, Carbon tetrachloride

Copyright© The Japanese Pharmacological Society 1995

[Back to TOC]