Jpn. J. Pharmacol. 69, 269-272 (1995)

KW-5092, a Novel Gastroprokinetic Agent, Reverses the Norepinephrine-Induced Decline of the Gastric Mucosal Blood Flow in Rats

Nobuyuki Kishibayashi and Akira Karasawa

Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411, Japan

Abstract: We examined the effects of KW-5092 ({1-[2-[[[5-(piperidinomethyl)-2-furanyl]methyl]- amino]ethyl]-2-imidazolidinylidene} propanedinitrile fumarate). a novel gastroprokinetic agent, on gastric mucosal blood flow (GMBF) in anesthetized rats. Intravenous infusion of KW-5092 (0.1 mg/kg/min for 30 min), which did not affect the basal GMBF, reversed the norepinephrine (1 microg/kg/min, i.v. infusion for 30 min)-induced decline of CMBF in the corpus and the antrum. The improvement by KW-5092 of the GMBF was abolished by atropine (0.1 mg/kg/min, i.v. infusion for 30 min). These results suggest that KW-5092, via cholinergic activation, could counteract the decline of GMBF induced by adrenergic activation

Keywords: KW-5092, Gastric mucosal blood flow, Norepinephrine

Copyright© The Japanese Pharmacological Society 1995

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