Jpn. J. Pharmacol. 87 (2), 164-166 (2001)

Beneficial Effect of a-Tocopherol in Renal Ischemia-Reperfusion in Rats

Ernani Luís Rhoden1,*, Luiz Pereira-Lima1, Cláudio Telöken2, Márcio Luís Lucas3, Adriane Belló-Klein4 and Cláudia Ramos Rhoden3

1Post-Graduation Course in Medical Clinical, Federal University of Rio Grande do Sul/Porto Alegre Clinical Hospital; and Post-Graduation Course of School of Medical Sciences/Santa Casa University Hospital; Porto Alegre, RS, Brazil
Department of 2Surgery and 3Pharmacology, Porto Alegre School of Medical Sciences/Santa Casa University Hospital, Porto Alegre, RS, Brazil
4Laboratory of Physiology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

*Corresponding author. FAX: +55-51-32284346, E-mail:

Abstract: We evaluated the effects of a-tocopherol (vitamin E) on the products of lipid peroxidation and serum creatinine levels in a rat model of renal ischemia-reperfusion. The animals were submitted to sham operation or renal ischemia-reperfusion, and they were pretreated with a-tocopherol or the vehicle saline. In four groups, we analyzed the lipid peroxidation products by measuring malondialdehyde and chemiluminescence levels. In the other three groups, we studied the serum creatinine levels after the procedures. In our study, the pretreatment with a-tocopherol reduced significantly the lipid peroxidation of renal cells and renal dysfunction induced by renal ischemia-reperfusion in rats.

Keywords: a-Tocopherol, Renal ischemia-reperfusion, Lipid peroxidation

[Back to TOC]