Jpn. J. Pharmacol. 87 (1), 90-92 (2001)

Inhibition of Expression of Ornithine Decarboxylase by c-myc Antisense Oligonucleotide at the Promotion Stage of Lung Tumorigenesis in Mice

Tomohiro Yano1,*, Yoshihisa Yano2, Saburo Horikawa3, Haruna Satoh1, Kiyokazu Hagiwara1, Tomio Ichikawa4 and Shuzo Otani2

1Division of Applied Food Research, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan
2Second Department of Biochemistry, Osaka City University Medical School, Abeno-ku, Osaka 545-8585, Japan
3Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan
4Department of Life Enviromental Sciences, Mukogawa Womens' College, Nishinomiya, Hyogo 663-8558, Japan

*Corresponding author. FAX: +81-3-3205-6549, E-mail:

Abstract: Regulation of ornithine decarboxylase (ODC) expression at a promotion stage of lung carcinogenesis is a key clue to suppress the cancer. In this study, we investigated that the ODC induction at the promotion stage of lung carcinogenesis in mice could be inhibited through the suppression of the expression of c-myc, a transcription factor for ODC. The treatment with c-myc antisense oligonucleotide decreased the carcinogen-elevated level of pulmonary ODC protein at the promotion stage, but the sense oligonucleotide had no influence on the level. Overall, it is possible that the induction of ODC in the carcinogenic process of lung is regulated at its transcriptional level.

Keywords: c-Myc, Ornithine decarboxylase, Lung cancer
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