Jpn. J. Pharmacol. 87 (1), 86-89 (2001)

Dosing Time-Dependent Effect of Trandolapril on the Prevention of Cardiac Hypertrophy in Rats With Aortic Banding

Koh-ichi Sugimoto*, Masami Ohmori, Atsuhiro Kawaguchi, Shuichi Tsuruoka and Akio Fujimura

Department of Clinical Pharmacology, Jichi Medical School, 3311-1 Minamikawachi, Tochigi 329-0498, Japan

*Corresponding author. FAX: +81-285-44-7562, E-mail:

Abstract: Trandolapril was given to male Wistar rats with aortic banding at 10 AM or 10 PM for 6 weeks to examine the influence of dosing time on the development of left ventricular mass (LVM). Aortic banding increased the LVM compared with the sham-operated animals (P<0.01). Trandolapril (1 mg/kg) at 10 AM reduced LVM (1.74 ± 0.04 [S.E.M.] mg/g) more than the dosing at 10 PM (1.92 ± 0.04 mg/g, P<0.05), suggesting that trandolapril has a dosing time-dependent effect in the prevention of cardiac hypertrophy in rats with aortic banding.

Keywords: Cardiac hypertrophy, Dosing time, Trandolapril
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