Jpn. J. Pharmacol. 86 (4), 451-453 (2001)

Effects of Histidine on Working Memory Deficits Induced by the 5-HT1A-Receptor Agonist 8-OH-DPAT

Shinji Isayama, Yukio Sugimoto, Miyuki Nishiga and Chiaki Kamei*

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan

*Corresponding author. FAX: +81-86-251-7939, E-mail:

Abstract: We investigated the effects of histidine on spatial memory deficits induced by the 5-HT1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.

Keywords: Histidine, 8-Hydroxy-2-(di-n-propylamino)tetralin, Radial maze performance
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