Jpn. J. Pharmacol. 86 (3), 366-368 (2001)

Opposite Effects of Calcium and Magnesium on the Central Blood Pressure Regulation in the Spontaneously Hypertensive Rats

Den'etsu Sutoo* and Kayo Akiyama

Institute of Medical Science, University of Tsukuba, Tsukuba 305-8575, Japan

*Corresponding author. FAX: +81-298-54-9817, E-mail:

Abstract: The effects of intracerebroventricular administration of calcium or magnesium on the blood pressure regulation in the brain were investigated. The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 mg/rat) and increased by magnesium chloride (20, 100 or 500 mg/rat). The depressor response induced by calcium was inhibited by magnesium chloride in a dose-dependent manner. Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain.

Keywords: Blood pressure in spontaneously hypertensive rats, Calcium/calmodulin-dependent dopamine synthesis, Magnesium
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