Jpn. J. Pharmacol. 86 (1), 127-129 (2001)

Postprandial Hyperlipidemia in Zucker Diabetic Fatty fa/fa Rats, an Animal Model of Type II Diabetes, and Its Amelioration by Acyl-CoA:Cholesterol Acyltransferase Inhibition

Koji Fujinami*, Kazuhiro Kojima, Katsumi Aragane and Jun Kusunoki

Central Research Laboratories, Fujirebio Inc., 51 Komiya-cho, Hachioji, Tokyo 192-0031, Japan

*Corresponding author. FAX: +81-426-46-8325, E-mail:

Abstract: Postprandial hyperlipidemia (PH) is frequently observed in diabetic patients. We performed an oral fat-loading test in Zucker diabetic fatty (ZDF) fa/fa rats, a model for type II diabetes, to determine whether PH was induced in the rats. Post fat-loading changes in serum cholesterol and triglyceride levels were significantly greater in the fa/fa rats than those seen in their lean littermates and an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor significantly reduced these levels by 24% and 31%, respectively. Therefore, we confirmed that PH appeared in ZDF fa/fa rats by fat loading and ACAT inhibition may be a potential treatment for PH.

Keywords: Postprandial hyperlipidemia, Zucker diabetic fatty rat, Acyl-CoA:cholesterol acyltransferase
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