Jpn. J. Pharmacol. 85 (3), 335-337 (2001)

Antinociceptive Effect of Vitamin K2 (Menatetrenone) in Diabetic Mice

Kenji Onodera1,*, Ko Zushida2 and Junzo Kamei2

1Department of Dental Pharmacology, Okayama University Dental School, Sikata-cho, Okayama 700-8525, Japan
2Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan
*Corresponding author. FAX: +81-86-235-6664

Abstract: The antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice was examined using a tail-pressure test. Intraperitoneal injection of menatetrenone (10-100 mg/kg) produced a dose-dependent increase in the nociceptive threshold in diabetic mice. There was no significant difference between non-diabetic and diabetic mice in the menatetrenone-induced changes in the nociceptive threshold. The results suggest the therapeutical usefulness of menatetrenone for treating painful diabetic neuropathy and osteoporosis.

Keywords: Vitamin K2 (menatetrenone), Antinociception, Painful diabetic neuropathy

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