Jpn. J. Pharmacol. 84 (3), 363-366 (2000)

Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa╩B During Hepatic Ischemia in Rats

Nobuaki Matsui, Ikuko Satsuki, Yuka Morita, Keiichi Inaizumi, Kazumi Kasajima, Reiko Kanoh, Nobuyuki Fukuishi and Masaaki Akagi*

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University,180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima 770-8514, Japan
*Corresponding author.╩╩FAX:+81-88-655-3051

Abstract: The present study was carried out to elucidate the relationship between the generation of reactive oxygen species (ROS) and an activation of nuclear factor (NF) kappa╩B in a hepatic ischemia-reperfusion model. During the ischemic period, the contents of xanthine oxidase (XOD) metabolites and thiobarbituric acid-reactive substances were significantly increased, and NF-kappa╩B was activated in the liver of rats. The activation of NF-kappa╩B was inhibited by pretreatment of allopurinol (10-100╩mg/kg, i.p.) in a dose-dependent manner. In conclusion, this suggests that the XOD-derived ROS may activate NF-kappa╩B during ischemia.

Keywords: Xanthine oxidase, Nuclear factor kappa╩B, Reactive oxygen species

Copyrightę The Japanese Pharmacological Society 2000

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