Jpn. J. Pharmacol. 84 (1), 93-96 (2000)

The Effects of Soybean Transphosphatidylated Phosphatidylserine on Cholinergic Synaptic Functions of Mice

Hideyuki Yamatoya, Masashi Sakai and Satoshi Kudo

Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 186-8650, Japan

Abstract: The effects of soybean transphosphatidylated phosphatidylserine (SB-tPS) on cholinergic synaptic functions were investigated using cerebral cortical synaptosomes from mice. Treatment of the synaptosomes with SB-tPS increased high K+-induced acetylcholine (ACh) release in a bell-shaped, dose-dependent manner without affecting ACh synthesis. SB-tPS (10 and 50╩mM) also enhanced synaptosomal synthesis of sn-glycero-3-phosphocholine, but did not affect phosphorylcholine synthesis. In contrast, the choline synthesis was significantly reduced as SB-tPS concentration increased. The present result that SB-tPS modified the cholinergic pathway can partly explain its nootropic functions.

Keywords: Phosphatidylserine, Acetylcholine, Synaptosome

Copyrightę The Japanese Pharmacological Society 2000

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