Jpn. J. Pharmacol. 84 (1), 89-92 (2000)

Effect of Mexiletine on Thermal Allodynia and Hyperalgesia in Diabetic Mice

Junzo Kamei and Ko Zushida

Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University,
4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract: The antinociceptive effect of mexiletine in diabetic mice was examined. Tail-flick latencies at heat intensity of 35 and 50╩V in diabetic mice were shorter than those in non-diabetic mice. In diabetic mice, mexiletine increased the tail-flick latency at 35╩V to the level observed in non-diabetic mice. The tail-flick latency at 50╩V in diabetic mice, but not in non-diabetic mice, was increased by pretreatment with capsaicin (0.56╩nmol, i.t., 24╩h). The antinociceptive effect of mexiletine in diabetic mice was reduced by capsaicin. These results suggest that the mexiletine-induced antinociception in diabetic mice involves the inhibition of the nociceptive transmission of capsaicin-sensitive primary afferent fibers.

Keywords: Mexiletine, Hyperalgesia, Diabetes

Copyrightę The Japanese Pharmacological Society 2000

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