Satoru Suzuki, Akito Kataoka* and Masayoshi Furushiro
Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 186-8650, Japan
*ĘTo whom correspondence should be addressed.
Abstract: The effect of intracerebroventricularly administered soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) on memory impairment was evaluated by a passive avoidance task. SB-tPS significantly prolonged the step-through latency induced by scopolamine treatment as in our previous report where SB-tPS was orally administered. The same doses of soybean phosphatidylcholine were ineffective. This result indicates that SB-tPS can act on the brain without any peripheral modification.
Keywords: Phosphatidylserine, Intracerebroventricular administration, Scopolamine-induced amnesia
Copyright© The Japanese Pharmacological Society 2000
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