Jpn. J. Pharmacol. 84 (1), 78-81 (2000)

Repeated Adenosine Pre-treatment Potentiates the Acute Effect of Methamphetamine in Rats

Atsuko Kawashimo, Takao Shimazoe*, Akiko Yoshimatsu and Shigenori Watanabe

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University 62, Fukuoka 812-8582, Japan
*╩To whom correspondence should be addressed.

Abstract: Adenosine was intraperitoneally (i.p.) injected to Wistar rats every 3╩days with a total of 5╩administrations. After a 7-day withdrawal, the animals were challenged with methamphetamine (0.5╩mg/kg, i.p.). The effect of methamphetamine on locomotor activity was significantly potentiated by repeated adenosine pre-treatment. Moreover, methamphetamine-induced dopamine release was also increased in the striatum. Meth-amphetamine-induced hyperactivity and dopamine release were significantly potentiated by repeated pre-treatment of an adenosine╩A1 agonist, N6-cyclohexyladenosine (0.5╩mg/kg, i.p.). These results suggest that the acute effect of methamphetamine is potentiated by repeated pre-treatment of adenosine via adenosine╩A1 receptors.

Keywords: Methamphetamine, Adenosine, Adenosine╩A1 receptor

Copyrightę The Japanese Pharmacological Society 2000

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