Jpn. J. Pharmacol. 83 (4), 362-364 (2000)

Cadmium Induces Expression of Metallothionein in Rat Dental Pulp

Yukihiko Tamura and Keiichi Ohya

Pharmacology, Department of Hard Tissue Engineering, Division of Bio-Matrix, Graduate School, Tokyo Medical and Dental University,
1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan

Abstract: Metallothionein (MT) is a metalloprotein with high affinity for certain heavy metals. In the present study, the ability of cadmium (Cd) to induce the synthesis of MT in dental pulp was investigated. Rats were injected subcutaneously with CdCl2 (1.5╩mg Cd/kg) daily for 7╩days. Expression of the MT gene was demonstrated by reverse transcription polymerase chain-reaction techniques. The results indicate that Cd induced MT in dental pulp of rat incisor and this may be involved in the cellular defense mechanism against Cd toxicity.

Keywords: Heavy metal, Metallothionein, Dental pulp

Copyrightę The Japanese Pharmacological Society 2000

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