Jpn. J. Pharmacol. 83 (4), 355-358 (2000)

Entrainment Function in the Suprachiasmatic Nucleus of Streptozotocin-Induced Diabetic Rats

Takao Shimazoe1, Junichi Ishida2, Miyuki Maetani1, Tomohiro Yakabe2, Masatoshi Yamaguchi2,
Kyoko Miyasaka3, Akira Kono4, Shigenori Watanabe1 and Akihiro Funakoshi4

1Department╩of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
2Department╩of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan
3Department╩of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan
4National╩Kyushu Cancer Center, Fukuoka 811-1395, Japan

Abstract: The term for re-entrainment to a new light-dark cycle in streptozotocin (STZ)-induced diabetic rats was significantly longer than that in control rats. In STZ-induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application. Therefore, 5-HT function in the hypothalamus is thought to be decreased in STZ-induced diabetic rats. These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ-induced diabetic rats. Therefore, 5-HT mechanisms may play an important role in the maintenance of this function.

Keywords: Streptozotocin, Suprachiasmatic nucleus, Entrainment

Copyrightę The Japanese Pharmacological Society 2000

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