Jpn. J. Pharmacol. 83 (4), 344-347 (2000)

Day/Night Variation of 5-Hydroxyindole Acetic Acid Concentration in Rat Cerebrospinal Fluid After Acute and Long-Term Administration of a Selective Serotonin Reuptake Inhibitor, Fluvoxamine

Toru Egashira1, Fusako Takayama1, Yasumitsu Yamanaka1, Kaori Takada2, Hiroshi Takeda2 and Teruhiko Matsumiya2

1Department of Pharmacology, Oita Medical University, 1-1, Idaigaoka, Hasama-machi, Oita 879-5593, Japan
2Department of Pharmacology, Tokyo Medical College, 6-1-1, Shinjuku, Tokyo 160-8402, Japan

Abstract: When 30 mg/kg, p.o. of fluvoxamine, a selective serotonin reuptake inhibitor, was administered, significant increases of 3-methoxy-4-hydroxyphenylglycol (MHPG) and 5-hydroxy indole-3-acetic acid (5-HIAA) contents in rat cerebrospinal fluid (CSF) were observed from two days after administration of fluvoxamine in both the light and dark periods and in the dark period of the light/dark cycle, respectively. In long-term treatment with 15 mg/kg, p.o. of fluvoxamine, the level of MHPG in CSF exhibited no difference, whereas the levels of 5-HIAA showed a significant increase during the light periods. These results suggest that fluvoxamine enhances the 5-HT system, but only with long-term treatment.

Keywords: Selective serotonin reuptake inhibitor, Monoamine metabolite, Cerebrospinal fluid

Copyright© The Japanese Pharmacological Society 2000

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