Jpn. J. Pharmacol. 83 (3), 277-278 (2000)

Ca2+-Independent Phospholipase A2 Inhibitor Impairs Spatial Memory of Mice

Shinichi Fujita, Yuji Ikegaya*, Nobuyoshi Nishiyama and Norio Matsuki

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
*╩To whom correspondence should be addressed.

Abstract: Pharmacological blockade of Ca2+-independent phospholipase╩A2 (PLA2) is reported to disintegrate hippocampal synaptic plasticity, which is thought to be the cellular mechanism underlying learning and memory. Therefore, we investigated the effect of the Ca2+-independent PLA2 inhibitor bromoenol lactone (BEL) on spontaneous alteration behaviors of mice. When 3╩nmol BEL was intracerebroventricularly injected 30╩min prior to the test, the mice showed a poor alternation ratio, compared with control animals. The data suggest that Ca2+-independent PLA2 activity is required for spatial memory.

Keywords: Phospholipase A2, Learning and memory, Spontaneous alternation behavior

Copyrightę The Japanese Pharmacological Society 2000

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