Jpn. J. Pharmacol. 83 (3), 269-272 (2000)

Effect of Zaldaride Maleate, an Antidiarrheal Compound,
on 16,16-Dimethyl Prostaglandin E2-Induced Intestinal Ion Secretion in Rats

Nobuo Aikawa, Akira Karasawa and Kenji Ohmori

Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.,
1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, Japan

Abstract: The effect of zaldaride, a calmodulin inhibitor, on 16,16-dimethyl prostaglandin╩E2 (dmPGE2)-induced intestinal ion secretion was investigated in rats. Zaldaride inhibited the dmPGE2-induced increase in water content in the colon, but not that in the small intestine. In the colonic mucosa, zaldaride attenuated the dmPGE2-induced short-circuit current; however, it did not affect the forskolin or dibutyryl cAMP-induced effect. These results suggest that zaldaride inhibits dmPGE2-induced intestinal ion secretion by reducing the activity of Ca2+/calmodulin-dependent adenylate cyclase linked to a receptor, and the colon may be an important site in the action of zaldaride.

Keywords: Zaldaride maleate, Calmodulin, Intestinal secretion

Copyrightę The Japanese Pharmacological Society 2000

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