Jpn. J. Pharmacol. 83 (2), 161-163 (2000)

Botulinum Toxin C3 Inhibits Hyperalgesia in Mice With Partial
Sciatic Nerve Injury

Xun Ye, Makoto Inoue and Hiroshi Ueda*

Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences,
1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
*╩To whom correspondence should be addressed.

Abstract: Mice with partial ligation of the sciatic nerve exhibited marked increase in the second phase nociceptive biting and licking behavior following intraplantar injection of formalin. The intrathecal pretreatment with botulinum toxin C3 dose-dependently attenuated the hyperalgesia in the second phase. These results suggest that a small G╩protein, Rho, and its downstream mechanisms are involved in the hyperalgesia following partial nerve injury.

Keywords: Botulinum toxin C3, Hyperalgesia, Sciatic nerve injury

Copyrightę The Japanese Pharmacological Society 2000

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