Jpn. J. Pharmacol. 82 (3), 261-264 (2000)


Effects of Nitric Oxide Scavenger, Carboxy-PTIO on Endotoxin-Induced Alterations in Systemic Hemodynamics in Rats

Katsuyuki Miura1, Shinya Yamanaka1, Tsuneyuki Ebara1, Michiaki Okumura2,
Masahito Imanishi2, Shokei Kim1, Tatsuya Nakatani3 and Hiroshi Iwao1


1Department of Pharmacology and 3Department of Urology, Osaka City University Medical School, Osaka 545-8585, Japan
2Osaka City General Hospital, Osaka 534-0021, Japan

Abstract: The present experiments were conducted to clarify the mode of cardiovascular action of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), a nitric oxide (NO) scavenger, during rat endotoxic shock by determining cardiac output and systemic arterial tone simultaneously. Lipopolysaccharide (LPS) (10 mg/kg, i.v.) decreased systemic blood pressure and cardiac output with transient increases in hematocrit and total vascular resistance. Administration of carboxy-PTIO (1.7 mg Š kg-1 Š min-1, i.v. for 60 min) at 90 min after LPS attenuated further decline in blood pressure and cardiac output without affecting changes in hematocrit or total vascular resistance. It is concluded that carboxy-PTIO attenuates endotoxin-induced hypotension predominantly by maintaining cardiac output in rat experimental endotoxic shock.

Keywords: Endotoxic shock, Nitric oxide, Carboxy-PTIO


Copyright© The Japanese Pharmacological Society 2000

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