Atsushi Takahashi1,2, Kenji Onodera1,*, Hisashi
Shinoda1 and Hideaki Mayanagi2
1Departmentof Pharmacology and 2Department of Pediatric Dentistry,
Tohoku University School of Dentistry, Sendai 980–8575, Japan
*To whom correspondence should be addressed.
Abstract: The effects of phenytoin and its major metabolite, 5–(4–hydroxyphenyl)–5–phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin–induced bone loss in vivo.
Keywords: Phenytoin, Calvaria, Bone resorption
Copyright© The Japanese Pharmacological Society 2000
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