Jpn. J. Pharmacol. 82 (1), 82-84 (2000)


Phenytoin and Its Metabolite, 5–(4–Hydroxyphenyl)–5–Phenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria

Atsushi Takahashi1,2, Kenji Onodera1,*, Hisashi Shinoda1 and Hideaki Mayanagi2


1Departmentof Pharmacology and 2Department of Pediatric Dentistry,
Tohoku University School of Dentistry, Sendai 980–8575, Japan
*To whom correspondence should be addressed.

Abstract: The effects of phenytoin and its major metabolite, 5–(4–hydroxyphenyl)–5–phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin–induced bone loss in vivo.

Keywords: Phenytoin, Calvaria, Bone resorption


Copyright© The Japanese Pharmacological Society 2000

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